Top 5 Most Brutal Female Serial Killers Kind, gentle, and caring are qualities that we often associate women with. It’s nearly impossible to imagine them committing a single act of violence, let alone kill a human being. But as much as we want to deny it, women can be cold-blooded killers, too. Take a deep breath as you might about to get horrified with these 5 most brutal female serial killers throughout history. 5. Karla Homolka Karla Homolka took the phrase “kill for love” rather too literally when she committed a crime, albeit as an accomplice, to impress her lover. In 1993, Homolka, a Canadian native, was convicted of manslaughter following a plea bargain with prosecutors for the rape and murder of at least two women, with one being her own sister. But these two unfortunate souls were just but the tip of the iceberg. According to reports, Homolka aided her husband, Paul Bernardo, kill a string of women in Scarborough, Ontario, between the years of 1990 and 1992.